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Keep an eye on Closely (1)pentobarbital will minimize the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to some minimize in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, advancement o